We as a result examined the associations of estradiol, estrone, and thirteen estrogen metabolites with breast cancer danger in prospectively saved urine samples from the populace-centered study of postmenopausal Females in Shanghai, China.
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Past, although not minimum, the true and reasonable implication of estrogens (in addition to androgens and corticosteroids) in the regulation of the metabolic hub of Vitality partition really should be clarified.
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The LC-MS/MS assay used to evaluate estrogens and estrogen metabolites is extremely delicate, certain, and reproducible. Also, the identical lab and assay have been useful for all comparison populations, along with the assay is strong to your sample processing and check here storage ailments typically Employed in epidemiologic scientific studies (
We also examined, on an exploratory foundation, how concentrations of estrogens/estrogen metabolites and estrogen metabolism profiles differ concerning Shanghai and Asian American postmenopausal Girls to determine regardless of whether differences could reveal greater breast cancer fees in the United States than in China.
†Odds ratios were estimated with conditional logistic regression and modified for age at cohort entry (